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Pull the unused STATdose cartridge from the carrying case For all patients taking Imitrex (sumatriptan injection): Tell all of your health care providers that you take Imitrex (sumatriptan injection). Your doctor or pharmacist will teach you how to. There have been concerns over its effects on the heart, but study after study shows it to be a very safe drug for most people. Pinch a 2-inch fold of skin between your thumb and index finger. This includes your doctors, nurses, pharmacists, and dentists. Make sure you can easily reach the syringe's plunger Step 4: Give the Injection 1. After you inserting the needle into the muscle take your hand off the skin. Sumatriptan injection may sometimes be given at home to patients who do not need to be in a hospital or clinic. 5 mL of IMITREX Injection 8 mg/mL solution contains 4 mg of. Recommended injection sites are the lateral portion of the thigh or deltoid area. Hold the syringe in your hand as though you are holding a pencil or a dart. 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